Magnetic-bead based isolation of RNA from tissue and cell samples • One-tube procedure minimizes risk of cross-contamination• Small elution volumes ≥ 50 μL• Suitable for manual and automated processing• Recombinant DNase included• Reducing agent TCEP included (no β-mercaptoethanol necessary) Technology Magnetic-bead technology Format Highly reactive superparamagnetic beads Processing Manual or automatedSample material Typical yield Elution volume ≥ 50 µL Preparation time Binding capacity Approx. 0.3 μg/μL beads NucleoMag® B-Beads, buffers, RNase-free rDNase 1 x 96 preps for the purification of total RNA - NucleoMag B-Beads, Buffers, Reducing Agent TCEP, RNase-free rDNase

8联管平行提取组织或细胞的总RNA，节约时间。rDNase可有效去除DNA污染。Isolation of total RNA in flexible 8-well strip format and for high throughput in approved 96-well format • Time-saving parallel isolation of total RNA• rDNase included for efficient removal of genomic DNA• Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination• RNA ready to use for any kind of enzymatic reaction• NucleoSpin® 8 / 96 RNA Core Kits: Kits with basic content focussed on automation platforms. Technology Silica-membrane technologySample material Fragment size > 200 bTypical yield A260/A280 1.90–2.10Typical RIN (RNA integrity number) > 9 (cells) / ≥ 7 (tissue) RNA ratio 28S/18S approx. 2.1Typical concentration 50–200 ng/µLElution volume 50–130 µLPreparation time 45 min/6 strips; 70 min/plateBinding capacity 100 µgNucleoSpin® RNA Binding Strips, MN Wash Plates, MN Square-well Blocks, Racks of Tube Strips, Elution Plate U-bottom, Self-adhering Foil, buffers, RNase-free rDNase 12 x 8 preps for the isolation of RNA from cells and tissue - NucleoSpin RNA Binding Strips, MN Wash Plates, MN Square-well Blocks , Racks of Tube Strips, Elution Plate U-bottom, Self-adhering Foil, buffers, RNase-free rDNase

Isolation of total RNA from whole blood (human or animal) in flexible 8-well strip format or approved 96-well format • Direct total blood lysis: very simple and convenient procedure (no selective erythrocyte lysis at 4 °C – complete processing at RT)• Compatible with common blood collection tubes and anticoagulants(e.g., EDTA, citrate, and heparin)• Suitable for fresh and frozen blood samples• rDNase included for efficient removal of genomic DNA • Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination Technology Silica-membrane technologyProcessing Manual or automated, vacuum or centrifugationSample material Fragment size > 200 ntTypical yield 1–8 µg (400 µL blood)Typical RNA quality (A260/A280) 1.9–2.1Elution volume 50–130 µLPreparation time: 60 min/6 strips 100 min/plateBinding capacity 100 µg Applications**• Manual or automated isolation of total RNA from fresh or frozen whole blood stabilized with, for example, EDTA, citrate, or heparin• Typical downstream applications: qRT-PCR, next generation sequencing, blotting, array technology ** RNA yield strongly depends on the leukocyte number in each individual blood sample. NucleoSpin® RNA Blood Binding Strips, MN Wash Plates, Square-well Blocks, Racks of Tube Strips, Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase, Liquid Proteinase K12 x 8 preps for the isolation of RNA from blood - NucleoSpin RNA Blood Binding Strips, MN Wash Plates, Racks of Tube Strips, Square-well Blocks, Elution Plates U-bottom, Self-adhering Foils, buffers, RNase-free rDNase, Liquid Proteinase K

96孔板高通量平行提取组织或细胞的总RNA，节约时间。rDNase可有效去除DNA污染。单孔载量100ugIsolation of total RNA in flexible 8-well strip format and for high throughput in approved 96-well format • Time-saving parallel isolation of total RNA• rDNase included for efficient removal of genomic DNA• Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination• RNA ready to use for any kind of enzymatic reaction• NucleoSpin® 8 / 96 RNA Core Kits: Kits with basic content focussed on automation platforms. Technology Silica-membrane technologySample material Fragment size > 200 bTypical yield A260/A280 1.90–2.10Typical RIN (RNA integrity number) > 9 (cells) / ≥ 7 (tissue) RNA ratio 28S/18S approx. 2.1Typical concentration 50–200 ng/µLElution volume 50–130 µLPreparation time 45 min/6 strips; 70 min/plateBinding capacity 100 µgNucleoSpin® RNA Binding Plates, MN Wash Plates, Square-well Blocks, Round-well Block Low, Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase x 96 preps for the isolation of RNA from cells and tissue - NucleoSpin RNA Binding Plates, MN Wash Plates, MN Square-well Blocks, Round-well Block Low , Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase

Magnetic-bead based isolation of RNA from tissue and cell samples • One-tube procedure minimizes risk of cross-contamination• Small elution volumes ≥ 50 μL• Suitable for manual and automated processing• Recombinant DNase included• Reducing agent TCEP included (no β-mercaptoethanol necessary) Technology Magnetic-bead technology Format Highly reactive superparamagnetic beads Processing Manual or automatedSample material Typical yield Elution volume ≥ 50 µL Preparation time Binding capacity Approx. 0.3 μg/μL beads NucleoMag® B-Beads, buffers, RNase-free rDNase 4 x 96 preps for the purification of total RNA - NucleoMag B-Beads, Buffers, RNase-free rDNase, Reducing Agent TCEP

Isolation of total RNA from whole blood (human or animal) in flexible 8-well strip format or approved 96-well format • Direct total blood lysis: very simple and convenient procedure (no selective erythrocyte lysis at 4 °C – complete processing at RT)• Compatible with common blood collection tubes and anticoagulants(e.g., EDTA, citrate, and heparin)• Suitable for fresh and frozen blood samples• rDNase included for efficient removal of genomic DNA • Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination Technology Silica-membrane technologyProcessing Manual or automated, vacuum or centrifugationSample material Fragment size > 200 ntTypical yield 1–8 µg (400 µL blood)Typical RNA quality (A260/A280) 1.9–2.1Elution volume 50–130 µLPreparation time: 60 min/6 strips 100 min/plateBinding capacity 100 µg Applications**• Manual or automated isolation of total RNA from fresh or frozen whole blood stabilized with, for example, EDTA, citrate, or heparin• Typical downstream applications: qRT-PCR, next generation sequencing, blotting, array technology ** RNA yield strongly depends on the leukocyte number in each individual blood sample. NucleoSpin® RNA Blood Binding Plates, MN Wash Plates, Square-well Blocks, Round-well Block Low, Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase, Liquid Proteinase K2 x 96 preps for the isolation of total RNA from blood - NucleoSpin RNA Blood Binding Plates, MN Wash Plates, Square-well Blocks, Round-well Blocks Low, Elution Plates U-bottom, Self-adhering Foils, buffers, RNase-free rDNase, Liquid Proteinase K

8联管平行提取组织或细胞的总RNA，节约时间。rDNase可有效去除DNA污染。Isolation of total RNA in flexible 8-well strip format and for high throughput in approved 96-well format • Time-saving parallel isolation of total RNA• rDNase included for efficient removal of genomic DNA• Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination• RNA ready to use for any kind of enzymatic reaction• NucleoSpin® 8 / 96 RNA Core Kits: Kits with basic content focussed on automation platforms. Technology Silica-membrane technologySample material Fragment size > 200 bTypical yield A260/A280 1.90–2.10Typical RIN (RNA integrity number) > 9 (cells) / ≥ 7 (tissue) RNA ratio 28S/18S approx. 2.1Typical concentration 50–200 ng/µLElution volume 50–130 µLPreparation time 45 min/6 strips; 70 min/plateBinding capacity 100 µgNucleoSpin® RNA Binding Strips, buffers, RNase-free rDNase 48 x 8 preps for the isolation of total RNA from cells and tissue - NucleoSpin RNA Binding Strips, buffers, RNase-free rDNase

96孔板高通量平行提取组织或细胞的总RNA，节约时间。rDNase可有效去除DNA污染。单孔载量100ugIsolation of total RNA in flexible 8-well strip format and for high throughput in approved 96-well format • Time-saving parallel isolation of total RNA• rDNase included for efficient removal of genomic DNA• Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination• RNA ready to use for any kind of enzymatic reaction• NucleoSpin® 8 / 96 RNA Core Kits: Kits with basic content focussed on automation platforms. Technology Silica-membrane technologySample material Fragment size > 200 bTypical yield A260/A280 1.90–2.10Typical RIN (RNA integrity number) > 9 (cells) / ≥ 7 (tissue) RNA ratio 28S/18S approx. 2.1Typical concentration 50–200 ng/µLElution volume 50–130 µLPreparation time 45 min/6 strips; 70 min/plateBinding capacity 100 µgNucleoSpin® RNA Binding Plates, MN Wash Plates, Square-well Blocks, Round-well Block Low, Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase x 96 preps for the isolation of RNA from cells and tissue - NucleoSpin RNA Binding Plates, MN Wash Plates MN Square-well Blocks, Elution Plates U-bottom, Self-adhering Foils, Round-well Block Low, buffers, RNase-free rDNase

Isolation of total RNA from whole blood (human or animal) in flexible 8-well strip format or approved 96-well format • Direct total blood lysis: very simple and convenient procedure (no selective erythrocyte lysis at 4 °C – complete processing at RT)• Compatible with common blood collection tubes and anticoagulants(e.g., EDTA, citrate, and heparin)• Suitable for fresh and frozen blood samples• rDNase included for efficient removal of genomic DNA • Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination Technology Silica-membrane technologyProcessing Manual or automated, vacuum or centrifugationSample material Fragment size > 200 ntTypical yield 1–8 µg (400 µL blood)Typical RNA quality (A260/A280) 1.9–2.1Elution volume 50–130 µLPreparation time: 60 min/6 strips 100 min/plateBinding capacity 100 µg Applications**• Manual or automated isolation of total RNA from fresh or frozen whole blood stabilized with, for example, EDTA, citrate, or heparin• Typical downstream applications: qRT-PCR, next generation sequencing, blotting, array technology ** RNA yield strongly depends on the leukocyte number in each individual blood sample. NucleoSpin® RNA Blood Binding Plates, MN Wash Plates, Square-well Blocks, Round-well Block Low, Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase, Liquid Proteinase K4 x 96 preps for the isolation of total RNA from blood - NucleoSpin RNA Blood Binding Plates, MN Wash Plates, Square-well Blocks, Round-well Blocks Low, Elution Plates U-bottom, Self-adhering Foils, buffers, RNase-free rDNase, Liquid Proteinase K

8联管平行提取组织或细胞的总RNA，节约时间。rDNase可有效去除DNA污染。Isolation of total RNA in flexible 8-well strip format and for high throughput in approved 96-well format • Time-saving parallel isolation of total RNA• rDNase included for efficient removal of genomic DNA• Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination• RNA ready to use for any kind of enzymatic reaction• NucleoSpin® 8 / 96 RNA Core Kits: Kits with basic content focussed on automation platforms. Technology Silica-membrane technologySample material Fragment size > 200 bTypical yield A260/A280 1.90–2.10Typical RIN (RNA integrity number) > 9 (cells) / ≥ 7 (tissue) RNA ratio 28S/18S approx. 2.1Typical concentration 50–200 ng/µLElution volume 50–130 µLPreparation time 45 min/6 strips; 70 min/plateBinding capacity 100 µgNucleoSpin® RNA Binding Strips, MN Wash Plates, MN Square-well Blocks, Racks of Tube Strips, Elution Plate U-bottom, Self-adhering Foil, buffers, RNase-free rDNase 60 x 8 preps for the isolation of RNA from cells and tissue - NucleoSpin RNA Binding Strips, MN Wash Plates, MN Square-well Blocks, Racks of Tube Strips, Elution Plates U-bottom, Self-adhering Foils, buffers, RNase-free rDNase

Isolation of total RNA from whole blood (human or animal) in flexible 8-well strip format or approved 96-well format • Direct total blood lysis: very simple and convenient procedure (no selective erythrocyte lysis at 4 °C – complete processing at RT)• Compatible with common blood collection tubes and anticoagulants(e.g., EDTA, citrate, and heparin)• Suitable for fresh and frozen blood samples• rDNase included for efficient removal of genomic DNA • Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination Technology Silica-membrane technologyProcessing Manual or automated, vacuum or centrifugationSample material Fragment size > 200 ntTypical yield 1–8 µg (400 µL blood)Typical RNA quality (A260/A280) 1.9–2.1Elution volume 50–130 µLPreparation time: 60 min/6 strips 100 min/plateBinding capacity 100 µg Applications**• Manual or automated isolation of total RNA from fresh or frozen whole blood stabilized with, for example, EDTA, citrate, or heparin• Typical downstream applications: qRT-PCR, next generation sequencing, blotting, array technology ** RNA yield strongly depends on the leukocyte number in each individual blood sample. NucleoSpin® RNA Blood Binding Strips, MN Wash Plates, Square-well Blocks, Racks of Tube Strips, Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase, Liquid Proteinase K60 x 8 preps for the isolation of RNA from blood - NucleoSpin RNA Blood Binding Strips, MN Wash Plates, Racks of Tube Strips, Square-well Blocks, Elution Plates U-bottom, Self-adhering Foils, buffers, RNase-free rDNase, Liquid Proteinase K

96孔板高通量平行提取组织或细胞的总RNA，节约时间。rDNase可有效去除DNA污染。单孔载量100ugIsolation of total RNA in flexible 8-well strip format and for high throughput in approved 96-well format • Time-saving parallel isolation of total RNA• rDNase included for efficient removal of genomic DNA• Processing under vacuum or by centrifugation• Suitable for manual and automated processing• Innovative MN Wash Plate minimizes risk of cross-contamination• RNA ready to use for any kind of enzymatic reaction• NucleoSpin® 8 / 96 RNA Core Kits: Kits with basic content focussed on automation platforms. Technology Silica-membrane technologySample material Fragment size > 200 bTypical yield A260/A280 1.90–2.10Typical RIN (RNA integrity number) > 9 (cells) / ≥ 7 (tissue) RNA ratio 28S/18S approx. 2.1Typical concentration 50–200 ng/µLElution volume 50–130 µLPreparation time 45 min/6 strips; 70 min/plateBinding capacity 100 µgNucleoSpin® RNA Binding Plates, MN Wash Plates, Square-well Blocks, Round-well Block Low, Elution Plates U-bottom, Self-adhering Foil, buffers, RNase-free rDNase 24 x 96 preps for the isolation of RNA from cells and tissue - NucleoSpin RNA Binding Plates, MN Wash Plates, MN Square-well Blocks, Round-well Block Low , Elution Plates U-bottom, Self-adhering Foils, buffers, RNase-free rDNas